Biochem/physiol Actions

Macrophage-derived chemokine (MDC) signals through the C-C chemokine receptor type 4 (CCR4). It chemo-attracts monocytes, dendritic cells and natural killer (NK) cells and aids in their function. The protein exerts human immunodeficiency virus (HIV) suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. It is expressed in various cancers and is involved in recruitment of regulatory T cells (Treg) within a tumor.

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General description

Macrophage-derived chemokine (MDC) is also known as C-C motif chemokine ligand 22 (CCL22). It is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and cluster of differentiation 4 (CD4) T cells. The gene encoding it is localized on human chromosome 16. Recombinant human MDC is an 8.0kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.